Bailey Zappe, a fourth-round pick out of Western Kentucky, took over for Brian Hoyer, who was hurt on a sack by Rashan Gary in the opening quarter against the Packers. Zappe finished 10 of 15 for 99 yards, with one TD, in the 27-24 OT loss.
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| Detroit Lions vs Los Angeles Chargers | |
| Type: Point Spread - Status: OPEN | |
| Detroit Lions | -105 |
| Los Angeles Chargers | -115 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| AFC Conference | -115 |
| NFC Conference | -105 |
