The end of the 2018 NFL season brought on the beginning of the Alliance of American Football — an upstart league that implemented slight rule changes compared to the NFL. The league got off to a hot start, with broadcasts on CBS and NFL Network, and enough former college and NFL stars to attract fans
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| Detroit Lions vs Los Angeles Chargers | |
| Type: Point Spread - Status: OPEN | |
| Detroit Lions | -105 |
| Los Angeles Chargers | -115 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| AFC Conference | -115 |
| NFC Conference | -105 |