Here are some of the players Indianapolis Colts coach Frank Reich will have to pay special attention to in his first season. IndyStar will break down each of the Indianapolis Colts’ 13 opponents for the 2018 season ahead of the team reporting to camp at Grand Park on July 25. New England Patriots
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| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| AFC Conference | -115 |
| NFC Conference | -105 |