The Christian McCaffrey trade, one of the NFL’s most fascinating deals in recent years, raises the ceiling for the 49ers for 2022. But what happens next year?
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| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| AFC Conference | -115 |
| NFC Conference | -105 |