Week 2 of the 2022 NFL season will feature a Monday Night Football doubleheader with the Bills hosting the Titans on ESPN and the Vikings hosting the Eagles on ABC.
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| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| AFC Conference | -115 |
| NFC Conference | -105 |