In late March, the NFL instituted a new rule stating that players cannot lower their heads to initiate and make contact with opponents, regardless of the situation. As part of the new rule, which is considered unneccessary roughness, players will receive a 15-yard penalty and could possibly be ejected
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| Detroit Lions vs Los Angeles Chargers | |
| Type: Point Spread - Status: OPEN | |
| Detroit Lions | -105 |
| Los Angeles Chargers | -115 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| AFC Conference | -115 |
| NFC Conference | -105 |
