Injuries are piling up in the first halves of the early afternoon games, with Indianapolis Colts quarterback Jacoby Brissett leading the list. Brissett hurt his left knee, leaving the game at Pittsburgh early in the second quarter after one of his offensive linemen fell on his leg shortly after he released
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| Detroit Lions vs Los Angeles Chargers | |
| Type: Point Spread - Status: OPEN | |
| Detroit Lions | -105 |
| Los Angeles Chargers | -115 |
| Philadelphia Eagles vs Dallas Cowboys | |
| Type: Total - Status: OPEN | |
| Under | -110 |
| Over | -110 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |
