Jonathan Taylor looked right at home in his first NFL start. The 21-year-old running back rushed 26 times for 101 yards and scored a touchdown in his first NFL start, leading the Indianapolis Colts past Minnesota 28-11. Taylor celebrated his first win inside Lucas Oil Stadium, after losing three Big Ten championship games in the stadium, in front of about 2,500 fans.
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| Detroit Lions vs Los Angeles Chargers | |
| Type: Point Spread - Status: OPEN | |
| Detroit Lions | -110 |
| Los Angeles Chargers | -110 |
| Philadelphia Eagles vs Dallas Cowboys | |
| Type: Total - Status: OPEN | |
| Under | -105 |
| Over | -115 |
| Pittsburgh Steelers vs Minnesota Vikings | |
| Type: Moneyline - Status: OPEN | |
| Pittsburgh Steelers | +110 |
| Minnesota Vikings | -130 |
| Cleveland Browns vs Minnesota Vikings | |
| Type: Point Spread - Status: OPEN | |
| Cleveland Browns | -110 |
| Minnesota Vikings | -110 |
| New York Jets vs Denver Broncos | |
| Type: Moneyline - Status: OPEN | |
| New York Jets | +230 |
| Denver Broncos | -280 |
| Jacksonville Jaguars vs Los Angeles Rams | |
| Type: Moneyline - Status: OPEN | |
| Jacksonville Jaguars | +175 |
| Los Angeles Rams | -210 |
| Indianapolis Colts vs Atlanta Falcons | |
| Type: Moneyline - Status: OPEN | |
| Indianapolis Colts | +105 |
| Atlanta Falcons | -125 |
| Green Bay Packers vs Philadelphia Eagles | |
| Type: Moneyline - Status: OPEN | |
| Green Bay Packers | +100 |
| Philadelphia Eagles | -120 |
| Miami Dolphins vs Washington Commanders | |
| Type: Moneyline - Status: OPEN | |
| Miami Dolphins | +120 |
| Washington Commanders | -140 |
| Philadelphia Eagles vs Chicago Bears | |
| Type: Moneyline - Status: OPEN | |
| Philadelphia Eagles | -340 |
| Chicago Bears | +270 |
| Washington Commanders vs Philadelphia Eagles | |
| Type: Moneyline - Status: OPEN | |
| Washington Commanders | +100 |
| Philadelphia Eagles | -120 |
| Chicago Bears vs Green Bay Packers | |
| Type: Moneyline - Status: OPEN | |
| Chicago Bears | +100 |
| Green Bay Packers | -120 |
| Kansas City Chiefs vs Denver Broncos | |
| Type: Moneyline - Status: OPEN | |
| Kansas City Chiefs | -210 |
| Denver Broncos | +175 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |
