The Texans can clinch the AFC South, the Bills look to shock the Patriots and the Rams hope to stay alive for a wild-card spot vs. the 49ers.
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| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| AFC Conference | -115 |
| NFC Conference | -105 |