For the sixth season in a row, the No. 1 or No. 2 seed from the AFC and NFC will advance to the Super Bowl. In the eyes of the odds makers, the top seeds in each conference are expected to make the trip to Mercedes-Benz Stadium in Atlanta for Super Bowl 53. Based off recent history, the Kansas City
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| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| AFC Conference | -115 |
| NFC Conference | -105 |