The Panthers’ 2016 season danced to the tune of a dysfunctional 1-5 start. A Week 7 bye wasn’t enough to forge a turnaround and the Panthers ended the year with a 6-10 record after their Super Bowl appearance in 2015. Key Additions: DE Julius Peppers, T Matt Kalil, CB Captain Munnerlyn Key Losses
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| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| AFC Conference | -115 |
| NFC Conference | -105 |
