While Deebo Samuel will return for the 49ers vs. the Rams, the team is still plagued by reserve/COVID-19 designations and injuries heading into Sunday’s game.
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| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| AFC Conference | -115 |
| NFC Conference | -105 |
