The New Orleans Saints settled their early-season travel plans, per a report from Jeff Duncan of the Times-Picayune. With road trips scheduled against the Los Angeles Rams in Week 2 and the Seattle Seahawks in Week 3, the Saints opted to stay on the West Coast rather than pack in so many cross-country
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| Detroit Lions vs Los Angeles Chargers | |
| Type: Point Spread - Status: OPEN | |
| Detroit Lions | -105 |
| Los Angeles Chargers | -115 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| AFC Conference | -115 |
| NFC Conference | -105 |