Effectively locked into their playoff seed last season, the Los Angeles Rams rested nearly all of their key players against the San Francisco 49ers in Week 17. The Rams will again host the 49ers in the regular-season finale on Sunday, but have plenty to play for this time around. Coach Sean McVay said
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| Detroit Lions vs Los Angeles Chargers | |
| Type: Point Spread - Status: OPEN | |
| Detroit Lions | -105 |
| Los Angeles Chargers | -115 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| AFC Conference | -115 |
| NFC Conference | -105 |
