RAMS (2016: 4-12) VS. INDIANAPOLIS (2016: 8-8) When Rams have the ball Coach Sean McVay is the play caller for an offense that should have all of its players available, including receiver Tavon Austin. Second-year quarterback Jared Goff, the No. 1 pick in the 2016 draft, had an up-and-down preseason,
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| Detroit Lions vs Los Angeles Chargers | |
| Type: Point Spread - Status: OPEN | |
| Detroit Lions | -105 |
| Los Angeles Chargers | -115 |
| Philadelphia Eagles vs Dallas Cowboys | |
| Type: Total - Status: OPEN | |
| Under | -110 |
| Over | -110 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |
