The Patriots are sporting a new look on defense and an attitude of leaving behind their lack of defense in the Super Bowl. Former defensive coordinator Matt Patricia is now head coach in Detroit. Longtime assistant Brian Flores is running the defense in New England without the formal title of coordinator
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| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| AFC Conference | -115 |
| NFC Conference | -105 |