The No. 9 Penn State Nittany Lions and No. 4 Ohio State Buckeyes meet on Saturday at 7:30 p.m. ET. This game, one of two on the Week 5 college football schedule that features a pair of Top-10 teams, will have major implications on who reaches the Big Ten Championship Game and College Football Playoff
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| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| AFC Conference | -115 |
| NFC Conference | -105 |
