Niners LBs coach Johnny Holland is dealing with a second bout of multiple myeloma, and will be away from the team beginning Sept. 6 as he undergoes treatment for the cancer.
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| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| AFC Conference | -115 |
| NFC Conference | -105 |