Offensive holding penalties in the NFL plummeted to their lowest Week 1 total in at least 20 seasons, an unexpected drop that was noticeable throughout the league’s first weekend of games.
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| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| AFC Conference | -115 |
| NFC Conference | -105 |