Tom Brady and the Tampa Bay Buccaneers will start the defense of their Super Bowl XXXVII title at home against the Dallas Cowboys to kick off the 2021 NFL season.
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| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| AFC Conference | -115 |
| NFC Conference | -105 |
