The Houston Texans have won the AFC South three times in coach Bill O’Brien’s five seasons, and they have led or shared the divisional lead all but three weeks this season. The Tennessee Titans last won the AFC South back in 2008 and haven’t swept the Houston Texans since 2007.
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| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| AFC Conference | -115 |
| NFC Conference | -105 |