NFL owners on Wednesday approved a number of rule changes for the 2021 season, including a proposal to expand the scope of information that replay officials could provide to on-field officiating crews during games.
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| Detroit Lions vs Los Angeles Chargers | |
| Type: Point Spread - Status: OPEN | |
| Detroit Lions | -105 |
| Los Angeles Chargers | -115 |
| Philadelphia Eagles vs Dallas Cowboys | |
| Type: Total - Status: OPEN | |
| Under | -115 |
| Over | -105 |
| Los Angeles Chargers vs Kansas City Chiefs | |
| Type: Total - Status: OPEN | |
| Under | -115 |
| Over | -105 |
| Indianapolis Colts vs Miami Dolphins | |
| Type: Moneyline - Status: OPEN | |
| Indianapolis Colts | -115 |
| Miami Dolphins | -105 |
| Cleveland Browns vs Cincinnati Bengals | |
| Type: Total - Status: OPEN | |
| Under | -110 |
| Over | -110 |
| Atlanta Falcons vs Tampa Bay Buccaneers | |
| Type: Total - Status: OPEN | |
| Under | -105 |
| Over | -115 |
| Jacksonville Jaguars vs Carolina Panthers | |
| Type: Moneyline - Status: OPEN | |
| Jacksonville Jaguars | -160 |
| Carolina Panthers | +135 |
| New England Patriots vs Las Vegas Raiders | |
| Type: Point Spread - Status: OPEN | |
| New England Patriots | -110 |
| Las Vegas Raiders | -110 |
| New Orleans Saints vs Arizona Cardinals | |
| Type: Point Spread - Status: OPEN | |
| New Orleans Saints | +100 |
| Arizona Cardinals | -120 |
| Washington Commanders vs New York Giants | |
| Type: Total - Status: OPEN | |
| Under | -110 |
| Over | -110 |
| New York Jets vs Pittsburgh Steelers | |
| Type: Total - Status: OPEN | |
| Under | -110 |
| Over | -110 |
| Denver Broncos vs Tennessee Titans | |
| Type: Moneyline - Status: OPEN | |
| Denver Broncos | -380 |
| Tennessee Titans | +290 |
| Seattle Seahawks vs San Francisco 49ers | |
| Type: Point Spread - Status: OPEN | |
| Seattle Seahawks | -110 |
| San Francisco 49ers | -110 |
| Green Bay Packers vs Detroit Lions | |
| Type: Moneyline - Status: OPEN | |
| Green Bay Packers | -120 |
| Detroit Lions | +100 |
| Los Angeles Rams vs Houston Texans | |
| Type: Point Spread - Status: OPEN | |
| Los Angeles Rams | -110 |
| Houston Texans | -110 |
| Buffalo Bills vs Baltimore Ravens | |
| Type: Total - Status: OPEN | |
| Under | -105 |
| Over | -115 |
| Chicago Bears vs Minnesota Vikings | |
| Type: Moneyline - Status: OPEN | |
| Chicago Bears | -120 |
| Minnesota Vikings | +100 |
| Kansas City Chiefs vs Philadelphia Eagles | |
| Type: Point Spread - Status: OPEN | |
| Kansas City Chiefs | -105 |
| Philadelphia Eagles | -115 |
| Pittsburgh Steelers vs Minnesota Vikings | |
| Type: Moneyline - Status: OPEN | |
| Pittsburgh Steelers | +105 |
| Minnesota Vikings | -125 |
| Cleveland Browns vs Minnesota Vikings | |
| Type: Point Spread - Status: OPEN | |
| Cleveland Browns | -110 |
| Minnesota Vikings | -110 |
| New York Jets vs Denver Broncos | |
| Type: Moneyline - Status: OPEN | |
| New York Jets | +230 |
| Denver Broncos | -280 |
| Jacksonville Jaguars vs Los Angeles Rams | |
| Type: Moneyline - Status: OPEN | |
| Jacksonville Jaguars | +175 |
| Los Angeles Rams | -210 |
| Indianapolis Colts vs Atlanta Falcons | |
| Type: Moneyline - Status: OPEN | |
| Indianapolis Colts | +100 |
| Atlanta Falcons | -120 |
| Green Bay Packers vs Philadelphia Eagles | |
| Type: Moneyline - Status: OPEN | |
| Green Bay Packers | +100 |
| Philadelphia Eagles | -120 |
| Miami Dolphins vs Washington Commanders | |
| Type: Moneyline - Status: OPEN | |
| Miami Dolphins | +165 |
| Washington Commanders | -195 |
| Dallas Cowboys vs Kansas City Chiefs | |
| Type: Moneyline - Status: OPEN | |
| Dallas Cowboys | +165 |
| Kansas City Chiefs | -195 |
| Philadelphia Eagles vs Chicago Bears | |
| Type: Moneyline - Status: OPEN | |
| Philadelphia Eagles | -320 |
| Chicago Bears | +260 |
| Washington Commanders vs Philadelphia Eagles | |
| Type: Moneyline - Status: OPEN | |
| Washington Commanders | +100 |
| Philadelphia Eagles | -120 |
| Chicago Bears vs Green Bay Packers | |
| Type: Moneyline - Status: OPEN | |
| Chicago Bears | +100 |
| Green Bay Packers | -120 |
| Kansas City Chiefs vs Denver Broncos | |
| Type: Moneyline - Status: OPEN | |
| Kansas City Chiefs | -210 |
| Denver Broncos | +175 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |
