There are still three NFL teams with no wins entering Week 4, and according to the latest NFL odds, each has a strong chance of a victory on Sunday. The Texans battle the Colts in an AFC South matchup at 1 p.m. ET. Indianapolis is a one-point home favorite in the current NFL odds after opening at -1.5
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| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| AFC Conference | -115 |
| NFC Conference | -105 |
