The Week 6 NFL schedule features four games with spreads of a touchdown or more. With large spreads potentially leading to lopsided scores, filling out optimal NFL DFS lineups requires keeping tabs on which games might get out of hand. At the end, one team will try to run out the clock while the other
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| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| AFC Conference | -115 |
| NFC Conference | -105 |
