The top seed of the NFC will be decided in the final regular-season game, when the Detroit Lions face the Minnesota Vikings on Sunday night. The winner will get a first-round playoff bye and home-field advantage until the Super Bowl.
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| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| AFC Conference | -115 |
| NFC Conference | -105 |