For all the focus on the big names that left San Francisco this offseason like longtime left tackle Joe Staley and defensive anchor DeForest Buckner, the reality is the 49ers will look much the same in 2020. The defending NFC champion Niners are returning 18 of 22 starters from a team that fell one quarter short of winning it all, the type of continuity that could be especially crucial during this virtual offseason. While many teams are trying to install new systems or get several new players up to speed while teams are spread out around the country during the COVID-19 pandemic, the 49ers are mostly intact.
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| Detroit Lions vs Los Angeles Chargers | |
| Type: Point Spread - Status: OPEN | |
| Detroit Lions | -110 |
| Los Angeles Chargers | -110 |
| Philadelphia Eagles vs Dallas Cowboys | |
| Type: Total - Status: OPEN | |
| Under | -105 |
| Over | -115 |
| Pittsburgh Steelers vs Minnesota Vikings | |
| Type: Moneyline - Status: OPEN | |
| Pittsburgh Steelers | +110 |
| Minnesota Vikings | -130 |
| Cleveland Browns vs Minnesota Vikings | |
| Type: Point Spread - Status: OPEN | |
| Cleveland Browns | -110 |
| Minnesota Vikings | -110 |
| Philadelphia Eagles vs Chicago Bears | |
| Type: Moneyline - Status: OPEN | |
| Philadelphia Eagles | -340 |
| Chicago Bears | +270 |
| Washington Commanders vs Philadelphia Eagles | |
| Type: Moneyline - Status: OPEN | |
| Washington Commanders | +100 |
| Philadelphia Eagles | -120 |
| Chicago Bears vs Green Bay Packers | |
| Type: Moneyline - Status: OPEN | |
| Chicago Bears | +100 |
| Green Bay Packers | -120 |
| Kansas City Chiefs vs Denver Broncos | |
| Type: Moneyline - Status: OPEN | |
| Kansas City Chiefs | -195 |
| Denver Broncos | +165 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |
