Emmanuel Sanders got acclimated in the San Francisco offense so fast that he caught a TD pass on his first drive with the team five days after being acquired by the 49ers in a trade from Denver. Sanders only built from there by posting the most prolific receiving performance this season for the 49ers
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| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| AFC Conference | -115 |
| NFC Conference | -105 |
