It’s tempting to pick against the New England Patriots this year. The up-and-coming Buffalo Bills have emerged as a popular pick to dethrone Bill Belichick’s bunch atop the AFC East. Tom Brady is gone – and so is some of the mystique that has surrounded the Patriots for most of the last two decades.
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| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| AFC Conference | -115 |
| NFC Conference | -105 |