In a duel of Heisman Trophy winners selected No. 1 overall, Cleveland quarterback Baker Mayfield led the Browns to a comeback win over Joe Burrow and the Cincinnati Bengals on Sunday.
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| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| AFC Conference | -115 |
| NFC Conference | -105 |
