Patrick Mahomes and Tom Brady might be the Madden 22 cover athletes, but it doesn’t mean they can beat family members when it comes to the classic EA Sports football game.
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| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| AFC Conference | -115 |
| NFC Conference | -105 |