Trey Lance’s right leg was put in an air cast before he exited the field on a cart. He was quickly ruled out for the game with an ankle injury, with Jimmy Garoppolo coming on to replace him against the Seahawks.
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| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| AFC Conference | -115 |
| NFC Conference | -105 |
