The San Francisco 49ers have had some extensive cap space the past few seasons, and they were aggressive in how they chose to use it in 2018. The team gave out signing bonuses to some players, but some of their bigger contracts used roster bonuses in year one. Both are paid out up front, but the difference
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| Detroit Lions vs Los Angeles Chargers | |
| Type: Point Spread - Status: OPEN | |
| Detroit Lions | -105 |
| Los Angeles Chargers | -115 |
| Philadelphia Eagles vs Dallas Cowboys | |
| Type: Total - Status: OPEN | |
| Under | -110 |
| Over | -110 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |