The Jaguars visit the Colts this weekend, coming off a bye-week at the halfway point of the season. Jacksonville is looking to bounce back and have a better second half of the season after going 3-5 through the teams first eight games. That includes going 0-2 in division games, with losses to the Titans
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| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| AFC Conference | -115 |
| NFC Conference | -105 |
