The sore left knee that sidelined Rams running back Todd Gurley against Arizona in Week 16 first became an issue after the team’s season opener. Gurley said he probably won’t know his status for the San Francisco game until Sunday.
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| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| AFC Conference | -115 |
| NFC Conference | -105 |