On Thursday night, the NFL world turns its attention to Kansas City, as the defending Super Bowl champion Chiefs host the Houston Texans in the 2020 NFL season opener. Without any preseason action due to the coronavirus pandemic, Thursday's game is the first taste of NFL football that fans have received since February's Super Bowl.
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| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| AFC Conference | -115 |
| NFC Conference | -105 |
