If the Giants are without star running back Saquon Barkley for a while, backup Dion Lewis is prepared. After the Giants (0-2) lost 17-13 to the Bears (2-0) Sunday at Soldier Field in Chicago, Lewis was unsure of how his workload would exactly change, but he remained ready for anything.
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| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| AFC Conference | -115 |
| NFC Conference | -105 |