Jalen Ramsey and Odell Beckham Jr. take their rivalry to the field to open the first NFL Sunday. Also, No. 2 pick Saquon Barkley makes his regular-season debut.
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| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| AFC Conference | -115 |
| NFC Conference | -105 |
