A classic NFC East clash is on the docket in Week 1, with two of the league’s premier running backs – Saquon Barkley and Ezekiel Elliott going head-to-head.
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| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| AFC Conference | -115 |
| NFC Conference | -105 |