After five weeks, fantasy owners of Dalvin Cook and Devonta Freeman are lamenting those draft picks, while those who gambled on Austin Ekeler and Tyler Boyd feel as if their fantasy IQs went up sharply. Week 6 constitutes a make-or-break moment for a host of players who have yet to live up to their preseason
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| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| AFC Conference | -115 |
| NFC Conference | -105 |
