The Eagles will go into the 2018 NFL season as reigning Super Bowl champions. That makes them the most wanted team through every game on their schedule. It will be tough for Philadelphia to make the NFC playoffs, let alone win the conference again, given their closest competition has reloaded to take
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| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| AFC Conference | -115 |
| NFC Conference | -105 |
