ESPN.com How many wins will the Browns have? Which team is expected to have the best record? NFL Nation reporters predict the over/under on win totals for all 32 NFL teams, as projected by ESPN’s Football Power Index, a predictive system that weighs offensive, defensive and special-teams efficiency
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| Detroit Lions vs Los Angeles Chargers | |
| Type: Point Spread - Status: OPEN | |
| Detroit Lions | -105 |
| Los Angeles Chargers | -115 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| AFC Conference | -115 |
| NFC Conference | -105 |