Panthers wide receiver Curtis Samuel injured his left ankle early in the third quarter, requiring help from trainers to hobble to the locker room. The team lists him as questionable to return. The Panthers also lost center, Tyler Larsen, who is questionable to return with a foot injury. Starting center
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| Detroit Lions vs Los Angeles Chargers | |
| Type: Point Spread - Status: OPEN | |
| Detroit Lions | -110 |
| Los Angeles Chargers | -110 |
| Philadelphia Eagles vs Dallas Cowboys | |
| Type: Total - Status: OPEN | |
| Under | -105 |
| Over | -115 |
| Pittsburgh Steelers vs Minnesota Vikings | |
| Type: Moneyline - Status: OPEN | |
| Pittsburgh Steelers | +110 |
| Minnesota Vikings | -130 |
| Cleveland Browns vs Minnesota Vikings | |
| Type: Point Spread - Status: OPEN | |
| Cleveland Browns | -110 |
| Minnesota Vikings | -110 |
| Philadelphia Eagles vs Chicago Bears | |
| Type: Moneyline - Status: OPEN | |
| Philadelphia Eagles | -340 |
| Chicago Bears | +270 |
| Washington Commanders vs Philadelphia Eagles | |
| Type: Moneyline - Status: OPEN | |
| Washington Commanders | +100 |
| Philadelphia Eagles | -120 |
| Chicago Bears vs Green Bay Packers | |
| Type: Moneyline - Status: OPEN | |
| Chicago Bears | +100 |
| Green Bay Packers | -120 |
| Kansas City Chiefs vs Denver Broncos | |
| Type: Moneyline - Status: OPEN | |
| Kansas City Chiefs | -200 |
| Denver Broncos | +170 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |
