Rookie defensive tackle Trysten Hill of the Dallas Cowboys is active for the first time in five games for the Thanksgiving matchup with Buffalo with Antwaun Woods sidelined by a knee injury. Dallas safety Jeff Heath is inactive for the second time in three games. Woods had already been declared out
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| Detroit Lions vs Los Angeles Chargers | |
| Type: Point Spread - Status: OPEN | |
| Detroit Lions | -105 |
| Los Angeles Chargers | -115 |
| Philadelphia Eagles vs Dallas Cowboys | |
| Type: Total - Status: OPEN | |
| Under | -110 |
| Over | -110 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |
