The big winners in Week 16 were the Saints , Patriots, Cowboys , Seahawks and Ravens. The big losers were the Steelers, Dolphins, Chiefs and Texans. Then the Texans became winners hours later, earning a playoff berth as they headed back to Houston on Sunday following a last-second 32-30 loss at Philadelphia
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| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| AFC Conference | -115 |
| NFC Conference | -105 |