The last time the Indianapolis Colts visited for the final preseason game, their starters could have driven over in a minivan and had plenty of room left for all their equipment. Their return trip could be just as meager. Two years ago, the Colts played only two starters — both on defense — in the final preseason game in Cincinnati.
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| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| AFC Conference | -115 |
| NFC Conference | -105 |