With Indianapolis Colts quarterback Jacoby Brissett out with an injured left knee, Brian Hoyer was set to make his 38th career NFL start with his sixth different team – and his first in more than two years.
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| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| AFC Conference | -115 |
| NFC Conference | -105 |