In a game for early control of the AFC South, the Indianapolis Colts showed they’re still in charge by dominating every facet of the game to build a 19-7 lead over the Jacksonville Jaguars through three quarters. Peyton Manning had plenty of time to pick apart the secondary, Joseph Addai came up with a big fourth-down run and the defense overwhelmed a surprisingly pass-happy Jaguars offense.
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| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| AFC Conference | -115 |
| NFC Conference | -105 |
