The Kansas City Chiefs placed former Pro Bowl running back Priest Holmes on the reserve/non-football injury list on Saturday, guaranteeing that his absence from the game will stretch to almost two years. After their first six games, the Chiefs will have a three-week window to activate the franchise career rushing leader.
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| Detroit Lions vs Los Angeles Chargers | |
| Type: Point Spread - Status: OPEN | |
| Detroit Lions | -105 |
| Los Angeles Chargers | -115 |
| Philadelphia Eagles vs Dallas Cowboys | |
| Type: Total - Status: OPEN | |
| Under | -105 |
| Over | -115 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |