The Tampa Bay Buccaneers kept rolling single coverage onto Tyreek Hill, and Patrick Mahomes kept zinging passes deep downfield to the fleet-footed Kansas City Chiefs wide receiver, who proceeded to waltz into the end zone three times while piling up 269 yards in a record-setting afternoon. It was just the latest example of the conundrum faced by Kansas City’s opposing defenses. When the Buffalo Bills steadfastly refused to let Mahomes beat them through the air, Clyde Edwards-Helaire led a ground game that ran 46 times for 245 yards.
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| Detroit Lions vs Los Angeles Chargers | |
| Type: Point Spread - Status: OPEN | |
| Detroit Lions | -105 |
| Los Angeles Chargers | -115 |
| Philadelphia Eagles vs Dallas Cowboys | |
| Type: Total - Status: OPEN | |
| Under | -110 |
| Over | -110 |
| Los Angeles Chargers vs Kansas City Chiefs | |
| Type: Total - Status: OPEN | |
| Under | -115 |
| Over | -105 |
| Indianapolis Colts vs Miami Dolphins | |
| Type: Moneyline - Status: OPEN | |
| Indianapolis Colts | -115 |
| Miami Dolphins | -105 |
| Cleveland Browns vs Cincinnati Bengals | |
| Type: Total - Status: OPEN | |
| Under | -110 |
| Over | -110 |
| Atlanta Falcons vs Tampa Bay Buccaneers | |
| Type: Total - Status: OPEN | |
| Under | -105 |
| Over | -115 |
| Jacksonville Jaguars vs Carolina Panthers | |
| Type: Moneyline - Status: OPEN | |
| Jacksonville Jaguars | -160 |
| Carolina Panthers | +135 |
| New England Patriots vs Las Vegas Raiders | |
| Type: Point Spread - Status: OPEN | |
| New England Patriots | -110 |
| Las Vegas Raiders | -110 |
| New Orleans Saints vs Arizona Cardinals | |
| Type: Point Spread - Status: OPEN | |
| New Orleans Saints | -105 |
| Arizona Cardinals | -115 |
| Washington Commanders vs New York Giants | |
| Type: Total - Status: OPEN | |
| Under | -110 |
| Over | -110 |
| New York Jets vs Pittsburgh Steelers | |
| Type: Total - Status: OPEN | |
| Under | -110 |
| Over | -110 |
| Denver Broncos vs Tennessee Titans | |
| Type: Moneyline - Status: OPEN | |
| Denver Broncos | -360 |
| Tennessee Titans | +280 |
| Seattle Seahawks vs San Francisco 49ers | |
| Type: Point Spread - Status: OPEN | |
| Seattle Seahawks | -110 |
| San Francisco 49ers | -110 |
| Green Bay Packers vs Detroit Lions | |
| Type: Moneyline - Status: OPEN | |
| Green Bay Packers | -115 |
| Detroit Lions | -105 |
| Los Angeles Rams vs Houston Texans | |
| Type: Point Spread - Status: OPEN | |
| Los Angeles Rams | -110 |
| Houston Texans | -110 |
| Buffalo Bills vs Baltimore Ravens | |
| Type: Total - Status: OPEN | |
| Under | -105 |
| Over | -115 |
| Chicago Bears vs Minnesota Vikings | |
| Type: Moneyline - Status: OPEN | |
| Chicago Bears | -120 |
| Minnesota Vikings | +100 |
| Kansas City Chiefs vs Philadelphia Eagles | |
| Type: Point Spread - Status: OPEN | |
| Kansas City Chiefs | -105 |
| Philadelphia Eagles | -115 |
| Pittsburgh Steelers vs Minnesota Vikings | |
| Type: Moneyline - Status: OPEN | |
| Pittsburgh Steelers | +105 |
| Minnesota Vikings | -125 |
| Cleveland Browns vs Minnesota Vikings | |
| Type: Point Spread - Status: OPEN | |
| Cleveland Browns | -110 |
| Minnesota Vikings | -110 |
| New York Jets vs Denver Broncos | |
| Type: Moneyline - Status: OPEN | |
| New York Jets | +230 |
| Denver Broncos | -280 |
| Jacksonville Jaguars vs Los Angeles Rams | |
| Type: Moneyline - Status: OPEN | |
| Jacksonville Jaguars | +175 |
| Los Angeles Rams | -210 |
| Indianapolis Colts vs Atlanta Falcons | |
| Type: Moneyline - Status: OPEN | |
| Indianapolis Colts | +100 |
| Atlanta Falcons | -120 |
| Green Bay Packers vs Philadelphia Eagles | |
| Type: Moneyline - Status: OPEN | |
| Green Bay Packers | +100 |
| Philadelphia Eagles | -120 |
| Miami Dolphins vs Washington Commanders | |
| Type: Moneyline - Status: OPEN | |
| Miami Dolphins | +165 |
| Washington Commanders | -195 |
| Dallas Cowboys vs Kansas City Chiefs | |
| Type: Moneyline - Status: OPEN | |
| Dallas Cowboys | +165 |
| Kansas City Chiefs | -195 |
| Philadelphia Eagles vs Chicago Bears | |
| Type: Moneyline - Status: OPEN | |
| Philadelphia Eagles | -320 |
| Chicago Bears | +260 |
| Washington Commanders vs Philadelphia Eagles | |
| Type: Moneyline - Status: OPEN | |
| Washington Commanders | +100 |
| Philadelphia Eagles | -120 |
| Chicago Bears vs Green Bay Packers | |
| Type: Moneyline - Status: OPEN | |
| Chicago Bears | +100 |
| Green Bay Packers | -120 |
| Kansas City Chiefs vs Denver Broncos | |
| Type: Moneyline - Status: OPEN | |
| Kansas City Chiefs | -210 |
| Denver Broncos | +175 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |