The Chiefs will begin the defense of their Super Bowl LVII title when they host the Lions on Thursday, Sept. 7. Other NFL schedule highlights include a rematch of last season’s NFC Championship Game in Week 13 between the Eagles and 49ers.
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| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| AFC Conference | -115 |
| NFC Conference | -105 |
